New Antibody Treatment Reawakens Immune System To Fight Pancreatic Cancer
Published in Diseases!, Tech News, Tools.
A new study explains how pancreatic tumors use a sugar coating to hide from the immune system and shows that a newly developed antibody can restore immune responses in mice.
Pancreatic cancer remains one of the most difficult cancers to treat and frequently does not respond to even the latest immunotherapy approaches.
Researchers at Northwestern Medicine have now identified a previously unknown reason for this resistance. They found that pancreatic tumors shield themselves from immune attack by using a sugar-based signal that effectively tells immune cells not to respond. The team also developed an antibody treatment designed to interrupt this protective signal.
In a study published in Cancer Research, the researchers detailed this mechanism for the first time and demonstrated that blocking it with a monoclonal antibody restores immune activity against pancreatic cancer cells in preclinical mouse models.
https://scitechdaily.com/new-antibody-treatment-reawakens-immune-system-to-fight-pancreatic-cancer/