Cellular Patch That can be Prepared in the Operating Room Helps Hearts Heal After Ischemic Injury
Published in Ischemia.
Heart attacks leave behind injured heart muscle that the body cannot fully repair on its own, leaving the damaged area weak, poorly supplied with blood, and prone to scarring. Healing damaged heart muscle remains a critical need to improve patient health. A team at Stanford University sought to address this problem directly at the site of injury by creating a living “CC patch” that can be laid over the damaged region to help it heal. Led by co-first authors and Stanford Cardiovascular Institute members Eric Pfrender, Sungwoo Kim, and John Farag, with senior authors Yunzhi Peter Yang and Yasuhiro Shudo, the researchers designed a patch that brings both the right cells and the right support structure to the heart’s surface when needed. Their innovative findings were recently published in Stem Cell Translational Medicine.
To build the patch, the team mixed two types of human blood vessel-forming cells (endothelial progenitor cells, which line blood vessels, and smooth muscle cells, which strengthen and stabilize them) into a medical-grade collagen solution. Within minutes, the solution forms a soft gel. The researchers then gently compress to squeeze out water. This “plastic compression” creates a thin, flexible, and surprisingly strong collagen sheet packed with living cells. The whole process takes less than an hour, producing a patch that surgeons can lift, bend, and place directly onto the injured area without it falling apart.