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A New Full-Scale 3D Structural Model of the Human Hippocampus

Published in Brain/Neurology, Memory.

Summary: Researchers have developed a new 3D, high-resolution model of the CA1 area of the human hippocampus.

Source: Human Brain Project

A new high-resolution model of the CA1 region of the human hippocampus has been developed by the Institute of Biophysics of the Italian National Research Council (CNR-IBF) and University of Modena e Reggio Emilia (UNIMORE), part of the Human Brain Project.

The single-cell resolution model, which replicates the structure and architecture of the area, along with the position and relative connectivity of the neurons, was developed from a full-scale dataset of high-resolution images.

The dataset is available in the BigBrain Atlas and it will be soon available on EBRAINS. According to the study, published in the journal Nature Computational Science, the same methodology could be applied to generate full-scale models of other human brain areas and also to be integrated in a co-simulation environment such as the The Virtual Brain.

“The amount of data on individual neurons of the human brain is very limited, both in terms of relative 3D coordinates and in terms of connectivity among neurons,” explains Michele Migliore from CNR-IBF, Palermo.