Cancer Vaccine Created via CRISPR Prevents and Stops Brain Tumors
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New vaccine for deadly brain cancer glioblastoma created with CRISPR-Cas9.
Innovative technologies such as the gene-editing tool CRISPR-Cas9 enable pioneering scientists to develop novel treatments for diseases such as cancer. A new study published in Science Translational Medicine funded by the National Institutes of Health unveils an innovative cancer vaccine developed with CRISPR-Cas9 that both terminates and prevents tumors from recurring in mice for a deadly type of brain cancer called glioblastoma (GBM).
“Here, we developed a bifunctional whole cancer cell-based therapeutic with direct tumor killing and immunostimulatory roles,” wrote Khalid Shah, MS, Ph.D., Vice Chairman, Department of Neurosurgery at Brigham and Women’s Hospital, along with the researchers from his lab where the study was performed. Shah is also a founding member of the Mass General Brigham healthcare system and an Associate Professor at Harvard Medical School.