Researchers Develop Novel 3D Bioprinting Platform to Aid Natural Cell Function Preservation
Published in Bioprinting.
A collaborative study headed by Professor Xiujie Wang at the Institute of Genetics and Developmental Biology of the Chinese Academy of Sciences, Professor Charlie Wang C. L. at The University of Manchester, and Professor Yongjin Liu at the TsingHua University, has announced a novel three-dimensional (3D) bioprinting platform.
Novel six-axis robot-based bioprinting system and its printing products. A. Six-axis robot bioprinting platform and the printed IGDB letters composed of eGFP-labeled endothelial cells; B. Bioprinted artificial blood vessel is capable of forming new capillaries (left and middle, green color is eGFP-labeled endothelial cells). Bioprinted vascularized cardiac tissue (right, green color is cardiac tissue and red color is vascular network); C. Two-robot cooperation platform (left) can simultaneously print different types of cells onto a complex-shaped vascular scaffold (middle) to form patterned cell organization (right). Image Credit: Institute of Genetics and Developmental Biology.
3D bioprinting, which integrates a 3D printer with bioinks (frequently consisting of biomaterials and cells) to fabricate tissue- or organ-mimicking structures, is one of the most hopeful technologies for in vitro human organ generation.
But the commonly utilized 3D bioprinting method is incapable of integrating blood vessel networks at the time of the bioprinting process and thus experiences difficulty when fabricating functional and long-lived complex organs as a result of the lack of nutrient supply to printed cells.