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{"id":2764,"date":"2026-08-07T00:00:51","date_gmt":"2026-08-07T00:00:51","guid":{"rendered":"https:\/\/jonathandespres.com\/cryonicsrevival\/?p=2764"},"modified":"2026-08-07T00:00:51","modified_gmt":"2026-08-07T00:00:51","slug":"tarebio-vaccines-for-any-cancer-or-infection-in-weeks","status":"publish","type":"post","link":"https:\/\/jonathandespres.com\/cryonicsrevival\/2026\/08\/07\/tarebio-vaccines-for-any-cancer-or-infection-in-weeks\/","title":{"rendered":"TareBio: Vaccines for any cancer or infection in weeks"},"content":{"rendered":"<div>\n<p><strong>TL;DR:<\/strong>\u00a0Our platform develops\u00a0<strong>personalized<\/strong>\u00a0or\u00a0<strong>population-level<\/strong>\u00a0vaccines for\u00a0<strong><em>any<\/em>\u00a0disease<\/strong>\u00a0in weeks by\u00a0<strong>changing\u00a0<em>only one input<\/em><\/strong>: the immune imprint. Instead of trying to predict which antigens might work, we read out immune cells already fighting the disease in the body and reverse-engineer antigens that activate them. We&#8217;ve already run our platform end-to-end and created a vaccine that cured cancer in mice.\u00a0We will be vaccinating our first patient within the year.<\/p>\n<p><img src=\"https:\/\/www.ycombinator.com\/media\/?type=post&amp;id=108804&amp;key=user_uploads%2F431020%2F46cdbd4d-72d9-4231-a781-01a886dd82a4&amp;variant=large\" alt=\"uploaded image\" \/><\/p>\n<p>View our launch video here:\u00a0<a href=\"https:\/\/www.youtube.com\/watch?v=ty7jA8ecY2o\">https:\/\/www.youtube.com\/watch?v=ty7jA8ecY2o<\/a><\/p>\n<div class=\"embed-container youtube relative pb-[56.25%] h-0\"><iframe class=\"absolute t-0 l-0 w-full h-full border-[1px] border-color-[#ddd]\" src=\"https:\/\/www.youtube.com\/embed\/ty7jA8ecY2o\" allowfullscreen=\"allowfullscreen\" data-mce-fragment=\"1\"><\/iframe><\/div>\n<p><strong>The vaccine bottleneck<\/strong><\/p>\n<p>For 200+ years, vaccines have been designed using the same workflow: study a pathogen or tumor,\u00a0<em>predict<\/em>\u00a0which antigens might trigger protection, vaccinate, and hopefully generate a good immune response. This works for simpler infections. It has struggled for decades on complex diseases like HIV, TB, Hep C, and nearly\u00a0<em>every cancer<\/em>. Currently, vaccine design is treated as a prediction problem.<\/p>\n<p><strong>What we do differently<\/strong><\/p>\n<p>Instead, we treat it as a readout problem. The\u00a0<strong>immune system has\u00a0<em>already solved<\/em><\/strong>\u00a0antigen selection in the body, it knows what it&#8217;s responding to and the best immune cells for the job. So, we flip the whole process around:<\/p>\n<ol>\n<li>Capture the immune cells already responding to a cancer or infection, the &#8220;<strong>immune imprint<\/strong>&#8220;<\/li>\n<li>Use this imprint to directly identify, or \u201c<strong>reverse engineer<\/strong>\u201d, activating antigens<\/li>\n<li>Build a\u00a0<strong>vaccine<\/strong>\u00a0from those antigens<\/li>\n<\/ol>\n<p><img src=\"https:\/\/www.ycombinator.com\/media\/?type=post&amp;id=108804&amp;key=user_uploads%2F431020%2F31744f0e-4a44-4aa9-aa2e-29d174a8d30a&amp;variant=large\" alt=\"uploaded image\" \/><\/p>\n<p>The same platform works for\u00a0<strong><em>any<\/em>\u00a0disease<\/strong>\u00a0by changing one input: the immune imprint. Function over prediction, no constrained search space, and the output is a vaccine that can generate durable immunity in the body, not a transient antibody conjugate or cellular therapy.<\/p>\n<p><strong>Proof<\/strong><\/p>\n<p>We built the full platform in mice and ran it end-to-end: identified antigens from the immune imprint of the cancer, designed a vaccine from them, and\u00a0<strong>cured lymphoma in mice.<\/strong>\u00a0Nothing about the technology is specific to lymphoma, it generalizes to any cancer or infection. We are using our technology to create both personalized (n=1) and population-level vaccines.<\/p>\n<p><strong>Why us<\/strong><\/p>\n<p>I&#8217;m Eta Atolia, founder and CEO. I built this platform over the last 8 years as part of my MD-PhD at UCLA-Caltech with funding from The Gates Foundation. Before this, I did my undergrad at MIT with most of my time dedicated to cancer immunotherapy and infectious disease research at the Koch and HMS. Our scientific advisory board includes Darrell Irvine, PhD (Vice Chair of Immunology at Scripps, Former MIT Professor of 22 years, world-renowned vaccine engineer) and Manish Butte, MD, PhD (Chief of Immunology at UCLA and expert rare disease clinician).<\/p>\n<p><strong>Our ask<\/strong><\/p>\n<p>We are actively working with organizations and individuals to create both population-level vaccines and personalized treatments.<\/p>\n<p>Helpful things as we build:<\/p>\n<ul>\n<li>If you have\u00a0<strong>patient tumor<\/strong>\u00a0<strong>or<\/strong>\u00a0<strong>blood samples<\/strong>, please reach out.<\/li>\n<li>Intros to\u00a0<strong>biotech + pharma<\/strong>\u00a0and\u00a0<strong>vaccine teams<\/strong>\u00a0for partnerships.<\/li>\n<li><strong>Immunologists, oncologists, infectious disease specialists,<\/strong>\u00a0and\u00a0<strong>ML engineers<\/strong>\u00a0who want to build this with us.<\/li>\n<\/ul>\n<p>If any of this resonates, reach out at\u00a0<a href=\"https:\/\/mail.google.com\/mail\/?view=cm&amp;fs=1&amp;tf=1&amp;to=contact@tarebio.com\" target=\"_blank\" rel=\"noopener\">contact@tarebio.com<\/a>.<\/p>\n<p><img src=\"https:\/\/www.ycombinator.com\/media\/?type=post&amp;id=108804&amp;key=user_uploads%2F431020%2Fe32e6406-ca9a-4740-9a77-48dd31f02e7f&amp;variant=large\" alt=\"uploaded image\" \/><\/p>\n<\/div>\n<div class=\"launch-footer\">\n<div class=\"row justify-end\"><a class=\"all-launches-link\" href=\"https:\/\/www.ycombinator.com\/launches\">See All Launches \u203a<\/a><\/div>\n<\/div>\n<div><\/div>\n<div><a href=\"https:\/\/www.ycombinator.com\/launches\/SIu-tarebio-vaccines-for-any-cancer-or-infection-in-weeks\">https:\/\/www.ycombinator.com\/launches\/SIu-tarebio-vaccines-for-any-cancer-or-infection-in-weeks<\/a><\/div>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>TL;DR:\u00a0Our platform develops\u00a0personalized\u00a0or\u00a0population-level\u00a0vaccines for\u00a0any\u00a0disease\u00a0in weeks by\u00a0changing\u00a0only one input: the immune imprint. Instead of trying to predict which antigens might work, we read out immune cells already fighting the disease in the body and reverse-engineer antigens that activate them. We&#8217;ve already run our platform end-to-end and created a vaccine that cured cancer in mice.\u00a0We will be [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[56,12],"tags":[],"_links":{"self":[{"href":"https:\/\/jonathandespres.com\/cryonicsrevival\/wp-json\/wp\/v2\/posts\/2764"}],"collection":[{"href":"https:\/\/jonathandespres.com\/cryonicsrevival\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/jonathandespres.com\/cryonicsrevival\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/jonathandespres.com\/cryonicsrevival\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/jonathandespres.com\/cryonicsrevival\/wp-json\/wp\/v2\/comments?post=2764"}],"version-history":[{"count":1,"href":"https:\/\/jonathandespres.com\/cryonicsrevival\/wp-json\/wp\/v2\/posts\/2764\/revisions"}],"predecessor-version":[{"id":2765,"href":"https:\/\/jonathandespres.com\/cryonicsrevival\/wp-json\/wp\/v2\/posts\/2764\/revisions\/2765"}],"wp:attachment":[{"href":"https:\/\/jonathandespres.com\/cryonicsrevival\/wp-json\/wp\/v2\/media?parent=2764"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/jonathandespres.com\/cryonicsrevival\/wp-json\/wp\/v2\/categories?post=2764"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/jonathandespres.com\/cryonicsrevival\/wp-json\/wp\/v2\/tags?post=2764"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}