The Neuron that Exists Only in Humans \ud83c\udf29\ufe0f (New Findings)<\/p>\n
Scientists have identified a previously unknown GABAergic neuron in the human cerebral cortex, one with a distinct structure, molecular signature, and function that doesn\u2019t exist in rodents.<\/p>\n
Meet the rosehip neuron \ud83c\udf39<\/p>\n
What makes it special:<\/p>\n
\ud83d\udd2c Human-specific: Discovered using single-nucleus RNA sequencing; its molecular signature is absent in the mouse cortex<\/p>\n
\ud83c\udf3f Distinct anatomy: Compact axonal arbor with large, bulbous \u201crosehip-like\u201d boutons<\/p>\n
\ud83e\uddec Unique molecular profile: GAD1 & CCK positive; negative for CNR1, SST, CALB2, and PVALB<\/p>\n
\ud83d\udd17 Tightly connected: Forms homotypic gap junctions with other rosehip cells<\/p>\n
\ud83c\udfaf Precision targeting: Synapses onto apical dendritic shafts of layer 3 pyramidal neurons<\/p>\n
\u26a1 Computational control: Suppresses back-propagating action potentials in tiny dendritic microdomains<\/p>\n
Rosehip neurons are positioned to exert powerful, localized control over dendritic computation\u2014the very processes thought to underlie learning, integration, and conscious perception. Their absence in animal models also raises an important question:<\/p>\n
\u27a1\ufe0f How much of human cognition relies on circuitry we\u2019ve never been able to study before?<\/p>\n
Credit Eszter Boldog and their team for the work!<\/p>\n","protected":false},"excerpt":{"rendered":"
The Neuron that Exists Only in Humans \ud83c\udf29\ufe0f (New Findings) Scientists have identified a previously unknown GABAergic neuron in the human cerebral cortex, one with a distinct structure, molecular signature, and function that doesn\u2019t exist in rodents. Meet the rosehip neuron \ud83c\udf39 What makes it special: \ud83d\udd2c Human-specific: Discovered using single-nucleus RNA sequencing; its molecular […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[14],"tags":[],"_links":{"self":[{"href":"https:\/\/jonathandespres.com\/cryonicsrevival\/wp-json\/wp\/v2\/posts\/2149"}],"collection":[{"href":"https:\/\/jonathandespres.com\/cryonicsrevival\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/jonathandespres.com\/cryonicsrevival\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/jonathandespres.com\/cryonicsrevival\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/jonathandespres.com\/cryonicsrevival\/wp-json\/wp\/v2\/comments?post=2149"}],"version-history":[{"count":1,"href":"https:\/\/jonathandespres.com\/cryonicsrevival\/wp-json\/wp\/v2\/posts\/2149\/revisions"}],"predecessor-version":[{"id":2150,"href":"https:\/\/jonathandespres.com\/cryonicsrevival\/wp-json\/wp\/v2\/posts\/2149\/revisions\/2150"}],"wp:attachment":[{"href":"https:\/\/jonathandespres.com\/cryonicsrevival\/wp-json\/wp\/v2\/media?parent=2149"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/jonathandespres.com\/cryonicsrevival\/wp-json\/wp\/v2\/categories?post=2149"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/jonathandespres.com\/cryonicsrevival\/wp-json\/wp\/v2\/tags?post=2149"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}