Deep brain stimulation technology enables the neural modulation with precise spatial control but requires permanent implantation of conduits. Here, we describe a photothermal wireless deep brain stimulation nanosystem capable of eliminating \u03b1-synuclein aggregates and restoring degenerated dopamine neurons in the substantia nigra to treat Parkinson\u2019s disease. This nanosystem (ATB NPs) consists of gold nanoshell, an antibody against the heat-sensitive transient receptor potential vanilloid family member 1 (TRPV1), and \u03b2-synuclein (\u03b2-syn) peptides with a near infrared\u2013responsive linker. ATB NPs by stereotactic injection target dopamine neurons expressing TRPV1 receptors in the substantia nigra. Upon pulsed near-infrared irradiation, ATB NPs, serving as nanoantennae, convert the light into heat, leading to calcium ion influx, depolarization, and action potentials in dopamine neurons through TRPV1 receptors. Simultaneously, \u03b2-synuclein peptides released from ATB NPs cooperate with chaperone-mediated autophagy initiated by heat shock protein, HSC70, to effectively eliminate \u03b1-synuclein fibrils in neurons. These orchestrated actions restored pathological dopamine neurons and locomotor behaviors of Parkinson\u2019s disease.<\/p>\n

https:\/\/www.science.org\/doi\/10.1126\/sciadv.ado4927?fbclid=IwY2xjawJcMJRleHRuA2FlbQIxMAABHTuDALL5sFrC1Oz6EG0Yh-7TZHLb6Yp2sH8287om6WhMkc-50Nd5hejWRw_aem_F-QVT9dLax6DzYAj7pOb2Q<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Deep brain stimulation technology enables the neural modulation with precise spatial control but requires permanent implantation of conduits. Here, we describe a photothermal wireless deep brain stimulation nanosystem capable of eliminating \u03b1-synuclein aggregates and restoring degenerated dopamine neurons in the substantia nigra to treat Parkinson\u2019s disease. This nanosystem (ATB NPs) consists of gold nanoshell, an […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[14,56,9,42],"tags":[],"_links":{"self":[{"href":"https:\/\/jonathandespres.com\/cryonicsrevival\/wp-json\/wp\/v2\/posts\/1956"}],"collection":[{"href":"https:\/\/jonathandespres.com\/cryonicsrevival\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/jonathandespres.com\/cryonicsrevival\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/jonathandespres.com\/cryonicsrevival\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/jonathandespres.com\/cryonicsrevival\/wp-json\/wp\/v2\/comments?post=1956"}],"version-history":[{"count":1,"href":"https:\/\/jonathandespres.com\/cryonicsrevival\/wp-json\/wp\/v2\/posts\/1956\/revisions"}],"predecessor-version":[{"id":1957,"href":"https:\/\/jonathandespres.com\/cryonicsrevival\/wp-json\/wp\/v2\/posts\/1956\/revisions\/1957"}],"wp:attachment":[{"href":"https:\/\/jonathandespres.com\/cryonicsrevival\/wp-json\/wp\/v2\/media?parent=1956"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/jonathandespres.com\/cryonicsrevival\/wp-json\/wp\/v2\/categories?post=1956"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/jonathandespres.com\/cryonicsrevival\/wp-json\/wp\/v2\/tags?post=1956"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}